BioCosm

REMOTE · BIOCOSM-MCP.FLY.DEV · SCANNED AUG 3

Biotech intelligence for AI agents: drugs, targets, diagnostics, PoS estimates, and writeups.

Available components

+3 this week 66 66 Trust /100

Trust breakdown (6 categories)

How this component scores in each security and reliability category. Every signal is checked automatically against the live server, and we only credit what we can confirm. How we score →

Endpoint Security57

The endpoint's TLS certificate is valid, in date, and uses a strong key. View diagnostics → Pass
Authorisation not fully verified: no authorisation is required to call this server, and 13 tool(s) never declared a destructiveHint. The MCP spec treats an absent hint as destructive by default, so we cannot call this surface safe. See how to fix → View diagnostics → Unverified
HTTPS is enforced; there's no plaintext access path. View diagnostics → Pass
HSTS check failed: the Strict-Transport-Security header is absent. See how to fix → View diagnostics → Fail
DNSSEC check failed: this domain isn't protected by DNSSEC. See how to fix → View diagnostics → Fail

Transport & Reachability100

Verified streamable-http transport via a live MCP handshake. View diagnostics → Pass

Schema Quality & AI Usability73

AI-judged instruction clarity (good).Pass
Tool/resource definitions use about 1284 tokens (~98/item across 13 items; 13 tools + 0 resources), lean.Pass
Usage-examples check failed: none of the tools include examples. See how to fix → Fail

Stability & Change Management27

Stability observed for 8 of 30 days with no destabilising changes; credit accrues until the full window elapses.Partial

Tool Coverage100

100% of tools have a non-trivial description (not blank, and not just the tool's name).Pass
100% of tool parameters carry a description.Pass
Structured output schemas are declared (100% of tools); any adoption earns full credit.Pass

Capabilities100

Implements a supported MCP spec version (2025-11-25); the latest is 2026-07-28.Pass

Install

Add this component to your MCP client. Where a client-specific snippet is available, pick your client below and copy it straight into your config; otherwise use the connection detail shown.

remote · biocosm-mcp.fly.dev

Claude Codex opencode OpenClaw Hermes Other

# add to Claude Code

claude mcp add --transport http nhoverte-biocosm https://biocosm-mcp.fly.dev/mcp

# ~/.codex/config.toml

[mcp_servers.nhoverte-biocosm]
url = "https://biocosm-mcp.fly.dev/mcp"

// opencode.json

{
  "$schema": "https://opencode.ai/config.json",
  "mcp": {
    "nhoverte-biocosm": {
      "type": "remote",
      "url": "https://biocosm-mcp.fly.dev/mcp",
      "enabled": true
    }
  }
}

# add to OpenClaw

openclaw mcp add nhoverte-biocosm --url https://biocosm-mcp.fly.dev/mcp --transport streamable-http

# ~/.hermes/config.yaml

mcp_servers:
  nhoverte-biocosm:
    url: "https://biocosm-mcp.fly.dev/mcp"

// mcp.json

{
  "mcpServers": {
    "nhoverte-biocosm": {
      "type": "http",
      "url": "https://biocosm-mcp.fly.dev/mcp"
    }
  }
}

The mcpServers block is a cross-client convention. Remote transports vary, so check your client's docs.

Changelog

Every change we have recorded for this component, newest first. Security-relevant changes are always shown. ▲ marks a change for the better, ▼ a change for the worse; unmarked changes are neutral.

2 Aug 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 20 to 23. That category is still filling its 30-day observation window: 6 days of observed history at the previous scan, 7 at this one. The score rises as the window fills, whether or not the server changes.
31 Jul 26 0
- We updated how we score, so this day's move reflects our rubric, not a change to the server See what changed → functional
29 Jul 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 7 to 10. That category is still filling its 30-day observation window: 2 days of observed history at the previous scan, 3 at this one. The score rises as the window fills, whether or not the server changes.
28 Jul 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 3 to 7. That category is still filling its 30-day observation window: 1 days of observed history at the previous scan, 2 at this one. The score rises as the window fills, whether or not the server changes.
27 Jul 26 0
- We updated how we score, so this day's move reflects our rubric, not a change to the server See what changed → functional
26 Jul 26 63

First indexed and scored.

Show 5 earlier entries Hide earlier entries

Diagnostics

Diagnostic detail from the automated scan of this channel: what the scanner observed at each step, so you can see exactly where a check passed or failed. It is informational only and never changes the trust score.

Captured 3 Aug 2026 · Probed https://biocosm-mcp.fly.dev/mcp

TLS valid

Negotiated TLS 1.3 with TLS_AES_128_GCM_SHA256 .

Subject	Issuer	Valid from	Valid until	Key	Signature	Serial
CN=*.fly.dev	CN=YE2,O=Let's Encrypt,C=US	21 Jun 2026	19 Sept 2026	ECDSA 256	ECDSA-SHA384	503153e73302e4a0c89ebb83c4a741aac04
SANs: *.fly.dev
CN=YE2,O=Let's Encrypt,C=US (CA)	CN=Root YE,O=ISRG,C=US	3 Sept 2025	2 Sept 2028	ECDSA 384	ECDSA-SHA384	4df3b15dd6c0784c507cd37b58e6f115
CN=Root YE,O=ISRG,C=US (CA)	CN=ISRG Root X2,O=Internet Security Research Group,C=US	13 May 2026	2 Sept 2032	ECDSA 384	ECDSA-SHA384	872165fc34b6e5fba8add5b3705fb53a
CN=ISRG Root X2,O=Internet Security Research Group,C=US (CA)	CN=ISRG Root X1,O=Internet Security Research Group,C=US	13 May 2026	2 Sept 2032	ECDSA 384	SHA256-RSA	6c8f1dc727c7117f7baf853ac980f9cd

DNSSEC insecure

Validation of biocosm-mcp.fly.dev. — Not signed

Zone	DS	Keys	Algorithms	Outcome
.	trust_anchor	20326, 38696	8, 8	Verified
dev.	present	60074	8	Verified
fly.dev.	absent			Unsigned (proven) parent-signed NSEC/NSEC3 proves an unsigned delegation

Authentication No authorisation required

The endpoint answered without asking for a token. Anyone who knows the URL can reach it.

Result	No authorisation required
HTTP status	200

Transports 2 probes

Transport	URL	Outcome	Status	Location
streamable-http	https://biocosm-mcp.fly.dev/mcp	Verified	200
http (plaintext)	http://biocosm-mcp.fly.dev/mcp	HTTPS enforced	301	https://biocosm-mcp.fly.dev/mcp

MCP tools — 13 exposed · ~1,052 tokens

The tools this component advertises to a client, with an estimated token cost for each. Expand a tool to see its parameters and schema. The per-tool counts are indicative and are not scored directly; the schema's total context footprint is one signal in Schema Quality & AI Usability.

Tool Tokens

find_by_phase ~102

List drugs/diagnostics at a specific clinical phase.

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Maximum results (default 100, max 500)
node_type	—	—	Optional filter — "drug", "pipeline", "diagnostic", "target"
phase	string	yes	One of "approved", "on_market", "phase3", "phase2", "phase1", "in_development", "cleared", "ldt", "ruo"

Name	Type	Req	Description
result	array	yes	—

No examples provided.

find_by_target ~66

Find all drugs that target a specific gene/protein.

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Maximum results (default 50, max 200)
target_gene	string	yes	Gene symbol or target name (e.g. "EGFR", "KRAS", "PD-1")

Name	Type	Req	Description
result	array	yes	—

No examples provided.

find_related ~145

Find nodes connected to a given node. Three relationship types are derived on-the-fly: - "drug_target": for a drug, the targets it hits (and vice versa for a target node, the drugs that hit it) - "same_company": drugs sharing a company with this node - "same_target_class": drugs with the same mechanism_class

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Maximum results per link type (default 30)
link_type	—	—	Optional filter — one of "drug_target", "same_target_class", "same_company". If None, returns all three groups.
node_id	string	yes	Source node identifier

Name	Type	Req	Description
result	—	yes	—

No examples provided.

get_company_portfolio ~50

Get a company's full drug/diagnostic portfolio from BioCosm.

Input Output Examples

Name	Type	Req	Description
company_name	string	yes	Company name (e.g. "Merck", "Roche", "Illumina")

Name	Type	Req	Description
result	—	yes	—

No examples provided.

get_coverage ~65

Report BioCosm's actual data coverage so you never mistake missing data for a real-world zero. An empty or absent field on a node means "not in BioCosm's data," never a true zero. BioCosm is AI-generated and may contain errors.

Input Output Examples

Input schema present but exposes no named parameters.

Structured output declared, but exposes no named fields.

No examples provided.

get_node ~145

Get full details for a single BioCosm node: identity and all name aliases, classification, gene targets and mechanism, therapeutic areas, companies, revenue history where available (sparse: ~100 drugs, mostly blockbusters, as annualized quarterly estimates; source links when present), probability-of- success predictions for pipeline drugs (with confidence intervals and contributing factors), structured clinical trial outcomes, external cross-references, and writeup availability. Empty fields mean "not in BioCosm's coverage," NOT zero or absent in reality.

Input Output Examples

Name	Type	Req	Description
node_id	string	yes	The node identifier (e.g. "pembrolizumab", "trastuzumab")

Name	Type	Req	Description
result	—	yes	—

No examples provided.

get_node_freshness ~56

Get freshness details for a single node: writeup age, enrichment hash match, staleness score, validation score.

Input Output Examples

Name	Type	Req	Description
node_id	string	yes	The node identifier (e.g. "pembrolizumab")

Name	Type	Req	Description
result	—	yes	—

No examples provided.

get_pos_score ~68

Get the Probability of Success estimate for a node, including the base rate, adjustment factors with reasoning, confidence interval, and model version. Returns None for nodes without a PoS score (typically only late-stage pipeline drugs are scored).

Input Output Examples

Name	Type	Req	Description
node_id	string	yes	Node identifier

Name	Type	Req	Description
result	—	yes	—

No examples provided.

get_staleness_report ~48

Get writeup staleness report: overall stats, top stale nodes, data source freshness.

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Number of top stale nodes to return (default 20)

Structured output declared, but exposes no named fields.

No examples provided.

get_stats ~44

Get a high-level overview of the BioCosm database: total nodes, writeups, companies, breakdowns by type/status/domain, validation scores, and recent pipeline runs.

Input Output Examples

Input schema present but exposes no named parameters.

Structured output declared, but exposes no named fields.

No examples provided.

get_writeup ~55

Get the full writeup for a BioCosm node, including all sections, citations, structured data, and validation score.

Input Output Examples

Name	Type	Req	Description
node_id	string	yes	The node identifier (e.g. "pembrolizumab")

Name	Type	Req	Description
result	—	yes	—

No examples provided.

list_by_therapeutic_area ~62

List all nodes in a given therapeutic area.

Input Output Examples

Name	Type	Req	Description
area	string	yes	Therapeutic area to search (e.g. "breast cancer", "non-small cell lung cancer")
limit	integer	—	Maximum results (default 50)

Name	Type	Req	Description
result	array	yes	—

No examples provided.

search_nodes ~146

Search BioCosm nodes by name, gene symbol, target, therapeutic area, or company. Results are ranked: exact name/brand matches first, then partial name matches, with a node-type prior (canonical drug/diagnostic nodes rank above gene-target nodes, which rank above ChEMBL salt-form duplicates). Nodes matched only via description/company/area rank last. Each result includes a `name` field for disambiguation.

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Maximum results to return (default 20, max 100)
query	string	yes	Search term (e.g. "breast cancer", "pembrolizumab", "Merck")

Name	Type	Req	Description
result	array	yes	—

No examples provided.

On this page

Handy links

Scoring key

80+ high trust
60–79 medium
below 60 low

How we score

Score history · last 30 days

26 Jul 3 Aug

Day	Score
26 Jul	63
27 Jul	63
28 Jul	64
29 Jul	65
30 Jul	65
31 Jul	65
1 Aug	65
2 Aug	66
3 Aug	66