Folklore Clinical Variant Interpretation MCP
REMOTE · API.HELENA.BIO · SCANNED SEP 20
Bioinformatics MCP for genomic variant interpretation, gene-disease evidence and literature.
Available components
How this component scores in each security and reliability category. Every signal is checked automatically against the live server, and we only credit what we can confirm. How we score → Why this is hard to score →
Endpoint Security66
- The endpoint's TLS certificate is valid, in date, and uses a strong key. View diagnostics → Pass
- No authorisation is required to call this server. Every tool declares its destructiveHint and none is destructive, so open access doesn't expose one. See how to fix → View diagnostics → Partial
- HTTPS enforcement could not be verified: the plaintext port answered with HTTP 404, which proves neither a plaintext path nor enforcement. View diagnostics → Unverified
- HSTS check failed: the Strict-Transport-Security header is absent. See how to fix → View diagnostics → Fail
- DNSSEC is configured correctly; the domain's records validate against the full chain to the root. View diagnostics → Pass
Transport & Reachability100
- Verified streamable-http transport via a live MCP handshake. View diagnostics → Pass
Schema Quality & AI Usability80
- 100% of prompts and resources have a non-trivial description (not blank, and not just the item's name).Pass
- AI-judged instruction clarity (excellent).Pass
- Context-footprint check failed: tool/resource definitions use about 1484 tokens (~185/item across 8 items; 7 tools + 1 resources), over budget; trim descriptions and params. See how to fix → Fail
- Usage-examples check failed: none of the tools include examples. See how to fix → Fail
Stability & Change Management100
- No destabilizing schema changes in the last 30 days.Pass
Tool Coverage100
- 100% of tools have a non-trivial description (not blank, and not just the tool's name).Pass
- 100% of tool parameters carry a description.Pass
- Structured output schemas are declared (100% of tools); any adoption earns full credit.Pass
Tool Safety100
- No prompt-injection markers were found in the server instructions, tool names or descriptions we captured.Pass
- We read all 7 captured tool definition(s), and no name or description among them implies an irreversible operation.Pass
- An AI judge read all 9 captured unit(s) of tool text and found none that tries to manipulate the model reading it.Pass
Capabilities100
- Implements a current MCP spec version (2026-07-28).Pass
- Supports UI / widget rendering.Pass
How do I install the Folklore Clinical Variant Interpretation MCP server?
Folklore Clinical Variant Interpretation MCP is a hosted endpoint at https://api.helena.bio/folklore/v1/mcp, so there is nothing to install locally. Ready-made configuration for Claude, Cursor, VS Code, Codex and 5 more is on this page, copied from each client's own documentation.
remote · api.helena.bio
claude mcp add --transport http helena-bioinformatics-folklore 'https://api.helena.bio/folklore/v1/mcp'
{
"mcpServers": {
"helena-bioinformatics-folklore": {
"url": "https://api.helena.bio/folklore/v1/mcp"
}
}
} {
"servers": {
"helena-bioinformatics-folklore": {
"type": "http",
"url": "https://api.helena.bio/folklore/v1/mcp"
}
}
} [mcp_servers.helena-bioinformatics-folklore] url = "https://api.helena.bio/folklore/v1/mcp"
{
"$schema": "https://opencode.ai/config.json",
"mcp": {
"helena-bioinformatics-folklore": {
"type": "remote",
"url": "https://api.helena.bio/folklore/v1/mcp",
"enabled": true
}
}
} openclaw mcp add helena-bioinformatics-folklore --url 'https://api.helena.bio/folklore/v1/mcp' --transport streamable-http
mcp_servers:
helena-bioinformatics-folklore:
url: "https://api.helena.bio/folklore/v1/mcp" {
"McpServers": {
"helena-bioinformatics-folklore": {
"Transport": "http",
"Url": "https://api.helena.bio/folklore/v1/mcp"
}
}
} assistant mcp add helena-bioinformatics-folklore -t streamable-http -u 'https://api.helena.bio/folklore/v1/mcp'
{
"mcpServers": {
"helena-bioinformatics-folklore": {
"type": "http",
"url": "https://api.helena.bio/folklore/v1/mcp"
}
}
} The mcpServers block is a cross-client convention. Remote transports vary, so check your client's docs.
Every change we have recorded for this component, newest first. Security-relevant changes are always shown. ▲ marks a change for the better, ▼ a change for the worse; unmarked changes are neutral.
- 11 Sept 26 0
- The server rewrote its instructions, which are the text every model session reads security
- Tool “search_variant_evidence” rewrote its description, which is the text the model reads security
- Schema quality: 1061 → 1484 ▼ functional
- Server version: 1.4.2 → 1.5.0 functional
- New tool “get_gene_disease_associations” functional
- New tool “search_disease_genes” functional
- 10 Sept 26 0
- Tool “search_variant_evidence” rewrote its description, which is the text the model reads security
- Server version: 1.4.1 → 1.4.2 functional
- 9 Sept 26 0
- Stability: 0.97 → pass security
- 8 Sept 26 +1
No change was recorded against any check on this day. Stability & Change Management went from 93 to 97. That category is still filling its 30-day observation window: 28 days of observed history at the previous scan, 29 at this one. The score rises as the window fills, whether or not the server changes.
- 6 Sept 26 +1
No change was recorded against any check on this day. Stability & Change Management went from 87 to 90. That category is still filling its 30-day observation window: 26 days of observed history at the previous scan, 27 at this one. The score rises as the window fills, whether or not the server changes.
- 4 Sept 26 +2
- DNSSEC: fail → pass ▲ security
- 2 Sept 26 +1
No change was recorded against any check on this day. Stability & Change Management went from 73 to 77. That category is still filling its 30-day observation window: 22 days of observed history at the previous scan, 23 at this one. The score rises as the window fills, whether or not the server changes.
- 31 Aug 26 +1
No change was recorded against any check on this day. Stability & Change Management went from 67 to 70. That category is still filling its 30-day observation window: 20 days of observed history at the previous scan, 21 at this one. The score rises as the window fills, whether or not the server changes.
Diagnostic detail from the automated scan of this channel: what the scanner observed at each step, so you can see exactly where a check passed or failed. It is informational only and never changes the trust score.
Captured 20 Sept 2026 · Probed https://api.helena.bio/folklore/v1/mcp
TLS valid
Negotiated TLS 1.3 with TLS_AES_128_GCM_SHA256 .
| Subject | Issuer | Valid from | Valid until | Key | Signature | Serial |
|---|---|---|---|---|---|---|
| CN=api.helena.bio | CN=YE1,O=Let's Encrypt,C=US | 31 Jul 2026 | 29 Oct 2026 | ECDSA 256 | ECDSA-SHA384 | 6771d20c762914c9ce8e1bf90853ecaba4c |
| SANs: api.helena.bio | ||||||
| CN=YE1,O=Let's Encrypt,C=US (CA) | CN=Root YE,O=ISRG,C=US | 3 Sept 2025 | 2 Sept 2028 | ECDSA 384 | ECDSA-SHA384 | 5ddd70dd31f801c85c186a7a04b80afe |
| CN=Root YE,O=ISRG,C=US (CA) | CN=ISRG Root X2,O=Internet Security Research Group,C=US | 13 May 2026 | 2 Sept 2032 | ECDSA 384 | ECDSA-SHA384 | 872165fc34b6e5fba8add5b3705fb53a |
| CN=ISRG Root X2,O=Internet Security Research Group,C=US (CA) | CN=ISRG Root X1,O=Internet Security Research Group,C=US | 13 May 2026 | 2 Sept 2032 | ECDSA 384 | SHA256-RSA | 6c8f1dc727c7117f7baf853ac980f9cd |
Background: What to check on a remote MCP endpoint →
DNSSEC secure
Validation of api.helena.bio. — Secure
| Zone | DS | Keys | Algorithms | Outcome |
|---|---|---|---|---|
| . | trust_anchor | 20326, 38696 | 8, 8 | Verified |
| bio. | present | 16334 | 8 | Verified |
| helena.bio. | present | 22743 | 13 | Verified |
| api.helena.bio. | Verified address RRset verified with the apex keys |
Authentication No authorisation required
The endpoint answered without asking for a token. Anyone who knows the URL can reach it.
| Result | No authorisation required |
|---|---|
| HTTP status | 200 |
Background: How OAuth 2.1 works in the 2026 MCP spec →
Transports 2 probes
| Transport | URL | Outcome | Status | Location |
|---|---|---|---|---|
| streamable-http | https://api.helena.bio/folklore/v1/mcp | Verified | 200 | |
| http (plaintext) | http://api.helena.bio/folklore/v1/mcp | Inconclusive | 404 |
The tools this component advertises to a client, with an estimated token cost for each. Expand a tool to see its parameters and schema. The per-tool counts are indicative and are not scored directly; the schema's total context footprint is one signal in Schema Quality & AI Usability. A tool's description is untrusted text the model reads on every call, which is what makes this list a security surface and not just an inventory: how tool poisoning works →
get_gene_disease_associations Find diseases associated with a gene ~169
Find diseases associated with one human gene for bioinformatics and clinical genomics research. Accepts an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance. Preserves conflicting and limited assertions. Gene-disease validity is not variant pathogenicity or a patient diagnosis. Use only a public gene identifier; no patient or case data. Results require professional review.
| Name | Type | Req | Description |
|---|---|---|---|
| gene | string | yes | One public human gene symbol or HGNC identifier, for example BRCA1 or HGNC:1100. No patient data. |
| limit | integer | – | Maximum number of source assertions per page, from 1 to 50. |
| offset | integer | – | Zero-based assertion offset; use the returned nextOffset when present. |
| Name | Type | Req | Description |
|---|---|---|---|
| associations | array | yes | – |
| contractVersion | string | yes | – |
| pagination | – | yes | – |
| query | – | yes | – |
| source | – | yes | – |
| status | string | yes | – |
| usage_boundary | – | yes | – |
| warnings | array | yes | – |
No examples provided.
get_publication_details Get details for a PubMed publication ~124
Retrieve the complete public bibliographic record for one PMID from Folklore's PubMed-derived genetics corpus. Returns the full abstract, authors, journal metadata, publication and MeSH terms, gene and variant mentions, retraction status, and PubMed/PMC links. Use after literature search when a user asks to inspect a specific publication. This is read-only professional literature evidence and contains no patient context.
| Name | Type | Req | Description |
|---|---|---|---|
| pmid | string | yes | One PubMed identifier to look up in Folklore's current corpus, as 1 to 12 digits without a PMID prefix. |
| Name | Type | Req | Description |
|---|---|---|---|
| contract_version | string | yes | – |
| publication | – | yes | – |
| usage_boundary | object | yes | – |
No examples provided.
search_disease_genes Find genes associated with a disease ~177
Find human genes associated with a disease for genomic analysis and rare-disease research. Accepts an exact MONDO identifier or a disease-name search. Returns matching ClinGen gene-disease validity assertions with inheritance, source reports and snapshot provenance. Name searches may match multiple diseases; preserve their distinct identities and do not infer a diagnosis. Use only a public disease name or identifier; no symptoms, patient or case data. Results require professional review.
| Name | Type | Req | Description |
|---|---|---|---|
| disease | string | yes | One public disease name or exact MONDO identifier (MONDO: followed by seven digits). A name search may match multiple distinct diseases. No symptoms or patient narrative. |
| limit | integer | – | Maximum number of source assertions per page, from 1 to 50. |
| offset | integer | – | Zero-based assertion offset; use the returned nextOffset when present. |
| Name | Type | Req | Description |
|---|---|---|---|
| associations | array | yes | – |
| contractVersion | string | yes | – |
| pagination | – | yes | – |
| query | – | yes | – |
| source | – | yes | – |
| status | string | yes | – |
| usage_boundary | – | yes | – |
| warnings | array | yes | – |
No examples provided.
search_literature_corpus Search the Folklore Literature Corpus ~229
Semantically search the public scientific Literature Corpus by a natural-language question. A question may include one or more PMID, DOI or PMCID references; those publications become exact anchors for finding related experiments, evidence and concepts across the corpus. Also accepts genes, variants, phenotypes, HPO and OMIM concepts. Include every known publication identifier in the query when the user asks to compare papers or find work related to a specific paper. Returns source-linked evidence candidates for professional review, not diagnoses, causality claims or treatment recommendations.
| Name | Type | Req | Description |
|---|---|---|---|
| cursor | – | – | Opaque continuation cursor from the preceding response for the same query and sort order; omit for the first page. |
| limit | integer | – | Maximum number of publications to return, from 1 to 25. |
| query | string | yes | Natural-language literature question or exact PMID, DOI, PMCID, gene, variant, phenotype, HPO, or OMIM query. Include every known publication identifier when comparing or finding related papers. |
| sort | string | – | Result ordering: relevance-ranked, newest publication first, or oldest publication first. |
| Name | Type | Req | Description |
|---|---|---|---|
| contract_version | string | yes | – |
| graph_degraded_reason | – | – | – |
| graph_used | boolean | – | – |
| graph_version | – | – | – |
| has_more | boolean | – | – |
| next_cursor | – | – | – |
| query | string | yes | – |
| results | array | yes | – |
| returned_count | integer | yes | – |
| searchable_fields | array | yes | – |
| semantic_degraded_reason | – | – | – |
| semantic_index_used | boolean | – | – |
| usage_boundary | object | yes | – |
No examples provided.
search_variant_evidence Classify or interpret a germline variant under ACMG/AMP ~266
Interpret this variant, explain what this HGVS means, or review this VUS. Use for human genomic variant analysis within bioinformatics workflows, including review of an already identified WGS/WES variant. Use when a user asks to classify or interpret pathogenicity, review a VUS, check available ClinVar assertions or population-frequency evidence, or resolve a variant notation. Classify, interpret or resolve one public GRCh38 germline SNV or simple indel smaller than 50 bp. Accepts coordinates, genomic/coding/protein HGVS, SPDI or rsID. Returns normalized variant identity, automated ACMG/AMP decision support, evidence, provenance and explicit limitations. This is variant-level decision support for professional review. It does not evaluate patient context and must not be presented as a diagnosis or treatment recommendation. Never choose a candidate when resolution is ambiguous.
| Name | Type | Req | Description |
|---|---|---|---|
| assembly | string | – | Reference genome assembly. Folklore currently accepts GRCh38 only. |
| query | string | yes | One germline nuclear SNV or simple indel to resolve and interpret; accepted forms include coordinates, genomic/coding/protein HGVS, SPDI, rsID, or a returned Folklore canonical_key in GRCh38:chrN:pos… |
| Name | Type | Req | Description |
|---|---|---|---|
| adapter_error | – | yes | – |
| contract_version | string | yes | – |
| record_url | string|null | yes | – |
| result | – | yes | – |
| usage_boundary | object | yes | – |
No examples provided.
search_variant_literature Find literature for a germline variant ~219
Resolve one public GRCh38 germline variant and retrieve relevant publications from Folklore's PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Use when a user asks what has been published about a variant, gene or associated condition. Associations do not establish causality, pathogenicity or a diagnosis and do not change Folklore's ACMG/AMP classification.
| Name | Type | Req | Description |
|---|---|---|---|
| assembly | string | – | Reference genome assembly. Folklore currently accepts GRCh38 only. |
| limit | integer | – | Maximum number of publications to return, from 1 to 25. |
| query | string | yes | One germline nuclear SNV or simple indel to resolve before retrieving its literature; this is a variant identifier, not a natural-language question. Accepts a returned Folklore canonical_key in GRCh3… |
| question | – | – | Optional natural-language focus applied after the variant is resolved, such as a condition or evidence question; do not put the variant identifier here. |
| Name | Type | Req | Description |
|---|---|---|---|
| contract_version | string | – | – |
| literature | – | yes | – |
| status | string | yes | – |
| usage_boundary | object | yes | – |
| variant_result | object | yes | – |
No examples provided.
support_helena Support Helena's free scientific infrastructure ~59
Learn how an agent can support or spread Helena's free public scientific infrastructure through the separate Helena Good MCP. This is an explicit opt-in information action. It does not initiate payment, create a relay, or change any Folklore scientific result.
Input schema present but exposes no named parameters.
Structured output declared, but exposes no named fields.
No examples provided.
What is the Folklore Clinical Variant Interpretation MCP server?
Folklore Clinical Variant Interpretation MCP is listed in the public MCP registry as io.github.helena-bioinformatics/folklore. Bioinformatics MCP for genomic variant interpretation, gene-disease evidence and literature. This page covers its hosted endpoint (https://api.helena.bio/folklore/v1/mcp).
Is the Folklore Clinical Variant Interpretation MCP server safe to use?
Folklore Clinical Variant Interpretation MCP scores 83 out of 100 on VerifyMCP. That is a record of what we were able to check automatically, not an endorsement. The category breakdown on this page shows every signal behind the number, including the ones we could not confirm.
What tools does the Folklore Clinical Variant Interpretation MCP server expose?
Folklore Clinical Variant Interpretation MCP exposes 7 tools: search_variant_evidence, search_variant_literature, get_publication_details, search_literature_corpus, support_helena, and 2 more. Their descriptions and schemas cost roughly 1,243 tokens of context every time the server is loaded.
Does the Folklore Clinical Variant Interpretation MCP server require authentication?
No. We connected to Folklore Clinical Variant Interpretation MCP without credentials and it answered, so anything it exposes is reachable by anyone who knows the address.
Is the Folklore Clinical Variant Interpretation MCP server still maintained?
Folklore Clinical Variant Interpretation MCP is still listed as active in the MCP registry. We last reached this channel on 20 September 2026. Those dates come from our own scans of the registry and the channel itself, not from anything the publisher announced.