Agentic Target Evidence

Fetch ChEMBL drug-mechanism and bioactivity signals for a ChEMBL target id.

Fetch ClinGen gene-disease validity classifications for a gene.

Count trials for a disease/condition regardless of target gene or intervention. Target-agnostic disease-level trial landscape (contrast with `clinicaltrials_search_trials`, which is gene-keyed). Uses count-only queries so a broad condition search never pages thousands of full study records.

Search ClinicalTrials.gov v2 API for studies involving the gene and disease. Records without posted results have scope='abstract'; those with results have scope='full_text'.

Fetch DepMap CRISPR gene effect and dependency scores for a gene.

Fetch DGIdb gene-category annotations for a gene. Returns category labels (e.g. DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE) each with the source databases asserting it, plus a convenience `is_druggable_genome` flag.

Fetch curated drug-gene interaction claims for a gene from DGIdb. Returns drugs known to interact with the gene's product, ranked by DGIdb's normalized interaction score, with mechanism (interaction type/directionality, e.g. inhibitor/INHIBITORY), supporting PMIDs, and contributing source databases. Set approved_only=True to restrict to drugs with regulatory approval.

Fetch regulatory-assay (ChIP-seq/DNase-seq/ATAC-seq) coverage at a gene locus.

Fetch disease-vs-control differential expression for a gene from Expression Atlas.

Fetch GenCC's per-submitter gene-disease validity classifications for a gene.

Fetch ClinVar variants overlapping this gene from gnomAD's integrated dataset.

Fetch gnomAD gene-level LoF/missense/synonymous constraint (LOEUF, pLI, pRec, MOEUF, syn_z).

Fetch observed high-confidence pLoF variants (natural knockouts) from gnomAD v4.

Fetch GTEx median tissue TPM and HPA protein localization for a gene.

Fetch genome-wide significant GWAS associations for a gene from EBI GWAS Catalog.

Resolve a gene symbol (including aliases/previous symbols) to its canonical HGNC record.

Fetch HPO phenotype breadth/specificity and inheritance-mode hints for a gene.

Fetch IMPC statistically significant knockout-mouse phenotype calls for a gene.

Resolve a disease name or existing ontology id to its MONDO term and cross-references.

Resolve a journal's OpenAlex quality signal from ISSN (preferred) or title.

Count FDA-approved drugs for an indication, regardless of target gene. Target-agnostic disease-level competitive landscape (contrast with `openfda_search_drug_labels`, which is gene-keyed). Returns the approved-drug count, drug names, a few mechanism-of-action examples, and which query path matched (`phrase` / `broad` / `none`).

Fetch FAERS adverse event summary for a drug name. Returns total, serious, and death report counts plus the top 25 reactions by frequency. FAERS has significant noise — treat as signal-generating, not ground truth (underreporting, confounders, duplicate submissions).

Search FDA drug labels for drugs mentioning the gene in mechanism of action or approved for the given indication. Returns up to 20 deduplicated label records (NON_SENSITIVE, public API).

Fetch gene-disease association scores from the Open Targets Platform. gene_id must be an Ensembl ID (e.g. ENSG00000012048 for BRCA1). disease_id must be an EFO ID (e.g. EFO_0000305 for breast carcinoma).

Fetch eQTL/pQTL ↔ GWAS colocalisations for a gene (OT Genetics). Returns molecular QTL signals for this gene that colocalize with GWAS loci (posterior H4 >= h4_threshold). gene_id must be an Ensembl ID.

Fetch known drugs targeting a gene from the Open Targets Platform. Returns drug name, type, clinical phase, approval status, mechanism of action, and the indication each drug is being developed for. gene_id must be an Ensembl ID.

Fetch GWAS Locus-to-Gene (L2G) evidence for a gene-disease pair (OT Genetics). Returns GWAS credible sets where this gene is prioritized as the likely causal gene for the given disease. gene_id must be an Ensembl ID; disease_id must be an EFO/MONDO ontology ID.

Fetch mouse knock-out phenotypes for a gene from Open Targets (MGI/IMPC). Returns phenotypic consequences of disrupting the mouse orthologue, establishing biological plausibility and early safety signals. gene_id must be an Ensembl ID.

Fetch safety liabilities for a gene from the Open Targets Platform. Returns curated adverse event and toxicity signals (hepatotoxicity, cardiotoxicity, nephrotoxicity, etc.) from FDA FAERS and toxicology databases. gene_id must be an Ensembl ID.

Fetch tractability evidence for a gene from the Open Targets Platform. Returns small-molecule and antibody tractability flags plus any other modalities (PROTAC, oligonucleotide, etc.).

Resolve a disease name (e.g. 'breast cancer') to its EFO/MONDO ID via Open Targets search.

Resolve a gene symbol (e.g. BRCA1) to its Ensembl ID via Open Targets search.

Fetch Orphanet rare-disease gene-disease associations for a gene.

Fetch Orphanet disease-prevalence records for a set of OrphaCodes.

Fetch Project Score (Sanger) CRISPR fitness/dependency data for a gene.

Fetch the abstract and metadata for a single PubMed article.

Return full-text availability info via PubMed Central. Returns None if the article is not in PMC.

Search PubMed using the NCBI E-utilities API. Respects the NCBI free-tier rate limit (3 req/s). Pass an NCBI_API_KEY env var to raise the limit to 10 req/s.

Fetch SPOKE Anatomy-Gene expression edges for a gene symbol.

Fetch SPOKE Disease-ASSOCIATES-Gene edges for a gene symbol.

Fetch the reviewed human UniProt protein profile (class, location, ChEMBL xref).

Search PatentsView for patents referencing the gene and disease. All results are classified NON_SENSITIVE (patent data is public).