ai.nullary/nullary

REMOTE · MCP.NULLARY.AI · SCANNED AUG 3

Negative results intelligence for drug discovery — query measured failures via MCP.

Available components

+8 this week 74 74 Trust /100

Trust breakdown (6 categories)

How this component scores in each security and reliability category. Every signal is checked automatically against the live server, and we only credit what we can confirm. How we score →

Endpoint Security80

The endpoint's TLS certificate is valid, in date, and uses a strong key. View diagnostics → Pass
No authorisation is required to call this server. Every tool declares its destructiveHint and none is destructive, so open access doesn't expose one. See how to fix → View diagnostics → Partial
HTTPS is enforced; there's no plaintext access path. View diagnostics → Pass
The HSTS (Strict-Transport-Security) header is present. View diagnostics → Pass
DNSSEC check failed: this domain isn't protected by DNSSEC. See how to fix → View diagnostics → Fail

Transport & Reachability100

Verified streamable-http transport via a live MCP handshake. View diagnostics → Pass

Schema Quality & AI Usability63

AI-judged instruction clarity (good).Pass
Context-footprint check failed: tool/resource definitions use about 4999 tokens (~142/item across 35 items; 35 tools + 0 resources), over budget; trim descriptions and params. See how to fix → Fail
Usage-examples check failed: none of the tools include examples. See how to fix → Fail

Stability & Change Management27

Stability observed for 8 of 30 days with no destabilising changes; credit accrues until the full window elapses.Partial

Tool Coverage100

100% of tools have a non-trivial description (not blank, and not just the tool's name).Pass
100% of tool parameters carry a description.Pass
Structured output schemas are declared (100% of tools); any adoption earns full credit.Pass

Capabilities100

Implements a supported MCP spec version (2025-11-25); the latest is 2026-07-28.Pass

Install

Add this component to your MCP client. Where a client-specific snippet is available, pick your client below and copy it straight into your config; otherwise use the connection detail shown.

remote · mcp.nullary.ai

Claude Codex opencode OpenClaw Hermes Other

# add to Claude Code

claude mcp add --transport http ai-nullary-nullary https://mcp.nullary.ai/mcp

# ~/.codex/config.toml

[mcp_servers.ai-nullary-nullary]
url = "https://mcp.nullary.ai/mcp"

// opencode.json

{
  "$schema": "https://opencode.ai/config.json",
  "mcp": {
    "ai-nullary-nullary": {
      "type": "remote",
      "url": "https://mcp.nullary.ai/mcp",
      "enabled": true
    }
  }
}

# add to OpenClaw

openclaw mcp add ai-nullary-nullary --url https://mcp.nullary.ai/mcp --transport streamable-http

# ~/.hermes/config.yaml

mcp_servers:
  ai-nullary-nullary:
    url: "https://mcp.nullary.ai/mcp"

// mcp.json

{
  "mcpServers": {
    "ai-nullary-nullary": {
      "type": "http",
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}

The mcpServers block is a cross-client convention. Remote transports vary, so check your client's docs.

Changelog

Every change we have recorded for this component, newest first. Security-relevant changes are always shown. ▲ marks a change for the better, ▼ a change for the worse; unmarked changes are neutral.

3 Aug 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 23 to 27. That category is still filling its 30-day observation window: 7 days of observed history at the previous scan, 8 at this one. The score rises as the window fills, whether or not the server changes.
1 Aug 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 17 to 20. That category is still filling its 30-day observation window: 5 days of observed history at the previous scan, 6 at this one. The score rises as the window fills, whether or not the server changes.
31 Jul 26 +4
- We updated how we score, so this day's move reflects our rubric, not a change to the server See what changed → functional
29 Jul 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 7 to 10. That category is still filling its 30-day observation window: 2 days of observed history at the previous scan, 3 at this one. The score rises as the window fills, whether or not the server changes.
28 Jul 26 +1

No change was recorded against any check on this day. Stability & Change Management went from 3 to 7. That category is still filling its 30-day observation window: 1 days of observed history at the previous scan, 2 at this one. The score rises as the window fills, whether or not the server changes.
27 Jul 26 0
- We updated how we score, so this day's move reflects our rubric, not a change to the server See what changed → functional
26 Jul 26 66

First indexed and scored.

Show 6 earlier entries Hide earlier entries

Diagnostics

Diagnostic detail from the automated scan of this channel: what the scanner observed at each step, so you can see exactly where a check passed or failed. It is informational only and never changes the trust score.

Captured 3 Aug 2026 · Probed https://mcp.nullary.ai/mcp

TLS valid

Negotiated TLS 1.3 with TLS_AES_128_GCM_SHA256 .

Subject	Issuer	Valid from	Valid until	Key	Signature	Serial
CN=mcp.nullary.ai	CN=YR1,O=Let's Encrypt,C=US	26 Jul 2026	24 Oct 2026	RSA 2048	SHA256-RSA	61bd13aee9c84eeb7ca21e7e9e0eb3a6139
SANs: mcp.nullary.ai
CN=YR1,O=Let's Encrypt,C=US (CA)	CN=Root YR,O=ISRG,C=US	3 Sept 2025	2 Sept 2028	RSA 2048	SHA256-RSA	a20253f15f2691c05dc1ce13b9bcca4e
CN=Root YR,O=ISRG,C=US (CA)	CN=ISRG Root X1,O=Internet Security Research Group,C=US	13 May 2026	2 Sept 2032	RSA 4096	SHA256-RSA	f24b6d17f9d9ad7cb1c9fea78782699f

DNSSEC insecure

Validation of mcp.nullary.ai. — Not signed

Zone	DS	Keys	Algorithms	Outcome
.	trust_anchor	20326, 38696	8, 8	Verified
ai.	present	3799	8	Verified
nullary.ai.	absent			Unsigned (proven) parent-signed NSEC/NSEC3 proves an unsigned delegation

Authentication No authorisation required

The endpoint answered without asking for a token. Anyone who knows the URL can reach it.

Result	No authorisation required
HTTP status	200

Header	Value
strict-transport-security	max-age=63072000

Transports 2 probes

Transport	URL	Outcome	Status	Location
streamable-http	https://mcp.nullary.ai/mcp	Verified	200
http (plaintext)	http://mcp.nullary.ai/mcp	HTTPS enforced	308	https://mcp.nullary.ai/mcp

MCP tools — 35 exposed · ~4,956 tokens

The tools this component advertises to a client, with an estimated token cost for each. Expand a tool to see its parameters and schema. The per-tool counts are indicative and are not scored directly; the schema's total context footprint is one signal in Schema Quality & AI Usability.

Tool Tokens

get_compound ~189

A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.

Input Output Examples

Name	Type	Req	Description
chembl_id	string	—	ChEMBL molecule ID, e.g. CHEMBL941.
inchi_key	string	—	Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid).
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
pubchem_cid	integer	—	PubChem Compound ID (CID).
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
compound	object	—	Identity: pref_name, chembl_id, inchi_key, max_phase.
findings	array	—	Every negative finding for this molecule.
query_metadata	object	yes	Echo of the resolved query.
returned_count	integer	—	—

No examples provided.

get_coverage ~25

Per-modality and per-source coverage stats (honest Phase-1 numbers).

Input Output Examples

Input schema present but exposes no named parameters.

Name	Type	Req	Description
by_modality	array	—	Per-modality finding counts.
by_source_type	array	—	Per-source finding counts.
curated_total	integer	—	—
query_metadata	object	yes	Echo of the resolved query.
total	integer	—	—

No examples provided.

get_finding_provenance ~32

Full provenance + detail for a single finding by id.

Input Output Examples

Name	Type	Req	Description
id	string	yes	finding UUID

Name	Type	Req	Description
finding	object	—	The finding with source, DOI/PMID, assay context, and confidence tier.
query_metadata	object	yes	Echo of the resolved query.

No examples provided.

get_model_card ~79

Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).

Input Output Examples

Name	Type	Req	Description
target	string	yes	gene symbol or UniProt accession (required)

Name	Type	Req	Description
query_metadata	object	yes	Echo of the resolved query.

No examples provided.

get_target_landscape ~91

Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).

Input Output Examples

Name	Type	Req	Description
target	string	yes	gene symbol or UniProt accession (required)

Name	Type	Req	Description
by_modality	array	—	Per-modality failed-agent counts.
by_outcome	array	—	Per-outcome counts.
query_metadata	object	yes	Echo of the resolved query.
summary	string	—	One-line natural-language summary.

No examples provided.

list_models ~39

Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.

Input Output Examples

Input schema present but exposes no named parameters.

Name	Type	Req	Description
query_metadata	object	yes	Echo of the resolved query.

No examples provided.

list_top_targets ~91

Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).

Input Output Examples

Name	Type	Req	Description
family	string	—	target family filter (optional)
limit	integer	—	Maximum number of findings to return (1–100, default 25).

Name	Type	Req	Description
query_metadata	object	yes	Echo of the resolved query.

No examples provided.

search_adc_linker_failures ~161

ADC failures attributed to linker chemistry.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_admet_failures ~160

Small-molecule ADMET failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_admet_failures_all_modalities ~163

ADMET failures across ALL modalities.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_ancestry_specific_failures ~164

Ancestry-specific CRISPR failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_bispecific_format_failures ~162

Bispecific format/engineering failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_developability_failures ~160

Antibody developability failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_drug_drug_interaction_failures ~150

Drug-drug interaction failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_adcs ~160

ADCs that failed at any stage.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_bispecifics ~163

Bispecifics that failed at any stage.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_clinical_antibodies ~163

Discontinued/terminated clinical antibodies.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_essentiality_screens ~164

Non-dependency / failed essentiality screens.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_guides ~161

Failed/ineffective CRISPR guides.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_oligonucleotides ~168

ASOs/siRNAs that failed engagement/developability.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_peptide_therapeutics ~161

Failed peptide therapeutics.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_protacs ~167

PROTACs that failed degradation/ternary/permeability.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_replications ~158

Findings that failed to replicate.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_selectivity ~159

Small molecules that failed selectivity.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_failed_vaccines ~155

Failed/terminated vaccines (by pathogen/indication).

Input Output Examples

Name	Type	Req	Description
indication	string	—	disease/indication
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_inactive_compounds ~162

Inactive small-molecule compound-target pairs.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_indication_history ~120

ALL failed approaches for an indication across every modality.

Input Output Examples

Name	Type	Req	Description
indication	string	yes	indication (required)
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_mechanism_failures ~165

Approaches that failed for a mechanism (by target).

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_oligo_delivery_failures ~162

Oligonucleotide delivery failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_pathogen_history ~121

Vaccine + antimicrobial + antibody failures for a pathogen.

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
pathogen	string	yes	pathogen name (required)
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_peptide_stability_issues ~163

Peptide stability/half-life failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_protac_e3_issues ~170

PROTAC E3-ligase recruitment / ternary failures.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_safety_failures ~161

Clinical/preclinical safety failures across modalities.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_target_history ~124

ALL failed approaches against a target across every modality.

Input Output Examples

Name	Type	Req	Description
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
target	string	yes	UniProt accession or gene symbol (required)
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

search_vaccine_immunogenicity_failures ~163

Failed vaccine immunogen designs.

Input Output Examples

Name	Type	Req	Description
compound	string	—	compound name, ChEMBL ID, or InChIKey
limit	integer	—	Maximum number of findings to return (1–100, default 25).
offset	integer	—	Number of findings to skip before this page, for pagination (default 0).
outcome	string	—	outcome filter (inactive, failed_safety, terminated, …)
target	string	—	UniProt accession or gene symbol
tier	string	—	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).

Name	Type	Req	Description
coverage_note	string	—	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
findings	array	—	Matching negative findings (same shape as the REST /findings endpoint).
has_more	boolean	—	True when more results exist beyond this page.
query_metadata	object	yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
returned_count	integer	—	Findings returned in this page.

No examples provided.

On this page

Handy links

Scoring key

80+ high trust
60–79 medium
below 60 low

How we score

Score history · last 30 days

26 Jul 3 Aug

Day	Score
26 Jul	66
27 Jul	66
28 Jul	67
29 Jul	68
30 Jul	68
31 Jul	72
1 Aug	73
2 Aug	73
3 Aug	74