# Guidetopharmacology (npm · @pipeworx/mcp-guidetopharmacology)

IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) MCP — BYO key. Expert-curated pharmacology database of…

- Trust score: 83/100 (high trust)
- Change this week: +4
- Registry status: active
- Liveness: live
- Owner verified: no
- Last scored: 2026-11-05

## Components

- remote · `gateway.pipeworx.io`: 77/100, [markdown](https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/guidetopharmacology-mcp.md), [page](https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/guidetopharmacology-mcp)
- npm · `@pipeworx/mcp-guidetopharmacology`: 83/100 (this document), [markdown](https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/pipeworx-mcp-guidetopharmacology.md), [page](https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/pipeworx-mcp-guidetopharmacology)

## Channel facts

- Registry: `npm`
- Package: `@pipeworx/mcp-guidetopharmacology`
- Version: `0.2.1`
- Transport: `stdio`

## Trust breakdown

How this component scores in each security and reliability category. Every signal is checked automatically from public evidence about the published package, including repeated runs of it in an isolated sandbox, and we only credit what we can confirm. Scores are 0–100 per category. Scoring method: https://verifymcp.io/docs/scoring (what has changed: https://verifymcp.io/docs/scoring/changelog)

Scored 2026-11-05.

- **Supply Chain Security**: 100/100
  - No malware found by supply-chain analysis.
  - No known CVEs affecting this package version or its production dependencies.
  - No install/post-install scripts declared.
  - No production dependencies, so there is no dependency health to assess.
- **Provenance & Transparency**: 97/100
  - Source repository is publicly reachable at the declared URL.
  - Cryptographically verified build provenance (signed, bound to pipeworx-io/mcp-guidetopharmacology).
  - Clear OSI-approved license (MIT).
  - Actively maintained (last published 3 days ago).
  - Disclosure check failed: no security disclosure policy was found in the source repository.
- **Schema Quality & AI Usability**: 67/100
  - AI-judged instruction clarity (excellent).
  - Context-footprint check failed: tool/resource definitions use about 787 tokens (~196/item across 4 items; 4 tools + 0 resources), over budget; trim descriptions and params.
  - Usage-examples check failed: none of the tools include examples.
- **Stability & Change Management**: 23/100
  - Stability observed for 7 of 30 days with no destabilising changes; credit accrues until the full window elapses.
- **Tool Coverage**: 100/100
  - 100% of tools have a non-trivial description (not blank, and not just the tool's name).
  - 100% of tool parameters carry a description.
- **Tool Safety**: 100/100
  - No prompt-injection markers were found in the server instructions, tool names or descriptions we captured.
  - We read all 4 captured tool definition(s), and no name or description among them implies an irreversible operation.
  - An AI judge read all 5 captured unit(s) of tool text and found none that tries to manipulate the model reading it.
- **Capabilities**: 100/100
  - Implements a supported MCP spec version (2025-11-25); the latest is 2026-07-28.

## Install

### How do I install the Guidetopharmacology MCP server?

Guidetopharmacology runs locally as an npm package, launched with npx -y @pipeworx/mcp-guidetopharmacology. Ready-made configuration for Claude, Cursor, VS Code, Codex and 5 more is on this page, copied from each client's own documentation.

### Claude

```bash
claude mcp add pipeworx-io-guidetopharmacology -- npx -y @pipeworx/mcp-guidetopharmacology
```

### Cursor

```json
{
  "mcpServers": {
    "pipeworx-io-guidetopharmacology": {
      "command": "npx",
      "args": [
        "-y",
        "@pipeworx/mcp-guidetopharmacology"
      ]
    }
  }
}
```

### VS Code

```json
{
  "servers": {
    "pipeworx-io-guidetopharmacology": {
      "command": "npx",
      "args": [
        "-y",
        "@pipeworx/mcp-guidetopharmacology"
      ]
    }
  }
}
```

### Codex

```bash
codex mcp add pipeworx-io-guidetopharmacology -- npx -y @pipeworx/mcp-guidetopharmacology
```

### opencode

```json
{
  "$schema": "https://opencode.ai/config.json",
  "mcp": {
    "pipeworx-io-guidetopharmacology": {
      "type": "local",
      "command": [
        "npx",
        "-y",
        "@pipeworx/mcp-guidetopharmacology"
      ],
      "enabled": true
    }
  }
}
```

### OpenClaw

```bash
openclaw mcp add pipeworx-io-guidetopharmacology --command npx --arg -y --arg @pipeworx/mcp-guidetopharmacology
```

### Hermes

```yaml
mcp_servers:
  pipeworx-io-guidetopharmacology:
    command: "npx"
    args: ["-y", "@pipeworx/mcp-guidetopharmacology"]
```

### Netclaw

```json
{
  "McpServers": {
    "pipeworx-io-guidetopharmacology": {
      "Transport": "stdio",
      "Command": "npx",
      "Arguments": [
        "-y",
        "@pipeworx/mcp-guidetopharmacology"
      ]
    }
  }
}
```

### Vellum

```bash
assistant mcp add pipeworx-io-guidetopharmacology -t stdio -c npx -a -y @pipeworx/mcp-guidetopharmacology
```

### Other

```json
{
  "mcpServers": {
    "pipeworx-io-guidetopharmacology": {
      "command": "npx",
      "args": [
        "-y",
        "@pipeworx/mcp-guidetopharmacology"
      ]
    }
  }
}
```

## Changelog

Every change recorded for this component, newest first. Days that predate change tracking, or that we cannot explain, say so: "we were watching and nothing happened" and "we were not watching" are different claims.

### 2026-11-05 (score 83, +1)

No change was recorded against any check on this day. Stability & Change Management went from 20 to 23. That category is still filling its 30-day observation window: 6 days of observed history at the previous scan, 7 at this one. The score rises as the window fills, whether or not the server changes.

### 2026-11-03 (score 82, +16)

- [security improvement] Malware scan: unverified → pass

### 2026-11-02 (score 66, −15)

- [security regression] Malware scan: pass → unverified
- [functional] Package version: 0.2.0 → 0.2.1

### 2026-11-01 (score 81, +1)

No change was recorded against any check on this day. Stability & Change Management went from 7 to 10. That category is still filling its 30-day observation window: 2 days of observed history at the previous scan, 3 at this one. The score rises as the window fills, whether or not the server changes.

### 2026-10-30 (score 80, +1)

No change was recorded against any check on this day. Stability & Change Management went from 0 to 3. That category is still filling its 30-day observation window: 0 days of observed history at the previous scan, 1 at this one. The score rises as the window fills, whether or not the server changes.

### 2026-10-29 (score 79)

First indexed and scored.

## MCP tools (4)

### `search_ligands` (~175 tokens)

Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for drug ligands by name. Returns matching ligands with their GtoPdb ligand id, type (e.g. Synthetic organic, Peptide, Antibody, Metabolite), and approval status. Use the returned ligand id with ligand_interactions to find which protein targets it acts on. Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey. Complements ChEMBL/DrugBank.

Input parameters:

- `limit` (number): Max results to return (default 15).
- `name` (string, required): Ligand name or fragment to search for, e.g. "aspirin" or "imatinib".

### `search_targets` (~169 tokens)

Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for protein targets by name. Returns matching targets with their GtoPdb target id, abbreviation, and type (e.g. GPCR, CatalyticReceptor, Enzyme, Transporter). Use the returned target id with target_interactions to find ligands that bind it. Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey. Complements ChEMBL/DrugBank.

Input parameters:

- `limit` (number): Max results to return (default 15).
- `name` (string, required): Target name or fragment to search for, e.g. "EGFR" or "dopamine receptor".

### `target_interactions` (~153 tokens)

List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey.

Input parameters:

- `limit` (number): Max interactions to return (default 25).
- `target_id` (number|string, required): GtoPdb target id, e.g. 1797 for EGFR.

### `ligand_interactions` (~232 tokens)

What proteins a drug acts on — the curated target interactions for a ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS), each with the target PROTEIN NAME, interaction type (Agonist/Antagonist/Inhibitor), action and binding affinity (pKi/pIC50). Pass the drug by name ("imatinib") and it is resolved for you; a GtoPdb ligand id also works. The response always names the ligand it actually read, so an id that turns out to be a different compound is visible rather than silent. Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey.

Input parameters:

- `ligand` (string): Drug/ligand name, e.g. "imatinib". Resolved against the GtoPdb ligand list.
- `ligand_id` (number|string): GtoPdb ligand id, e.g. 4139 for aspirin. Optional — give this OR ligand.
- `limit` (number): Max interactions to return (default 25).

## Diagnostics

Captured diagnostic sections: Provenance, Dependencies. The full working is on the page: https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/pipeworx-mcp-guidetopharmacology#diagnostics

## Score history

- 2026-11-05: 83
- 2026-11-04: 82
- 2026-11-03: 82
- 2026-11-02: 66
- 2026-11-01: 81
- 2026-10-31: 80
- 2026-10-30: 80
- 2026-10-29: 79

## Common questions

### What is the Guidetopharmacology MCP server?

Guidetopharmacology is an MCP server listed in the public MCP registry as io.github.pipeworx-io/guidetopharmacology. IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) MCP, BYO key. Expert-curated pharmacology database of… This page covers its npm package (@pipeworx/mcp-guidetopharmacology).

### Is the Guidetopharmacology MCP server safe to use?

Guidetopharmacology scores 83 out of 100 on VerifyMCP. We found no known CVEs affecting it as of 5 November 2026. It declares no install or post-install scripts. Its build provenance is signed and verified. That is a record of what we were able to check automatically, not an endorsement. The category breakdown on this page shows every signal behind the number, including the ones we could not confirm.

### What tools does the Guidetopharmacology MCP server expose?

Guidetopharmacology exposes 4 tools: search_ligands, search_targets, target_interactions, ligand_interactions. Their descriptions and schemas cost roughly 729 tokens of context every time the server is loaded.

### Is the Guidetopharmacology MCP server still maintained?

Guidetopharmacology is still listed as active in the MCP registry. We last reached this channel on 5 November 2026. Those dates come from our own scans of the registry and the channel itself, not from anything the publisher announced.

### What licence is the Guidetopharmacology MCP server under?

Guidetopharmacology declares the MIT licence, which is OSI-approved. That covers the source only, and says nothing about the cost of any service it calls.

## Links

- npm package: https://www.npmjs.com/package/@pipeworx/mcp-guidetopharmacology
- Socket report: https://socket.dev/npm/package/@pipeworx/mcp-guidetopharmacology
- Repository: https://github.com/pipeworx-io/mcp-guidetopharmacology
- Website: https://pipeworx.io/packs/guidetopharmacology
- Changelog RSS feed: https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/pipeworx-mcp-guidetopharmacology.xml
- Changelog JSON feed: https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/pipeworx-mcp-guidetopharmacology.json
- HTML version of this page: https://verifymcp.io/servers/pipeworx-io-guidetopharmacology/pipeworx-mcp-guidetopharmacology